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- https://patents.google.com/patent/US5929212A/enUS5929212A - CD3 specific recombinant antibody - Google Patents... DNA sequence encoding the amino acid sequence of a polypeptide effector ... The fully chimeric OKT3 antibody (chimeric light chain and chimeric heavy chain) ...
- PubMedhttps://pubmed.ncbi.nlm.nih.gov/8902633/Cloning and sequencing of the VH and V kappa genes of an anti ...... antibody (OKT3) using the reverse transcription-polymerase chain reaction method. ... Amino Acid Sequence; Animals; Antibodies, Monoclonal / biosynthesis ...
- https://www.rcsb.org/structure/1sy61SY6: Crystal Structure of CD3gammaepsilon ... - RCSB PDBMay 25, 2004 ... OKT3 binds to an atypically small area of CD3 epsilon and has a low affinity for the isolated CD3 epsilon gamma heterodimer. The structure of ...
- https://www.sciencedirect.com/science/article/pii/S0165247809001655Novel humanized anti-CD3 antibodies induce a predominantly ...Aug 15, 2009 ... In this work, we developed two humanized versions of OKT3. The development strategy was to use the closest human germline sequence to receive ...
- https://patents.google.com/patent/US6750325B1/enUS6750325B1 - CD3 specific recombinant antibody - Google PatentsEspecially the RAM may comprise amino acid sequences, whether variable region, CDR or other, derived from the specific anti-CD3 MAb (OKT3) hereinafter ...
- Bio-Radhttps://www.bio-rad-antibodies.com/monoclonal/human-cd3-antibody-okt3-mca6146.htmlAnti Human CD3 Antibody, clone OKT3 | Bio-RadMouse anti Human CD3 antibody, clone OKT3, recognizes T-cell surface glycoprotein CD3 epsilon chain (CD3ε), also known as T-cell surface antigen T3/Leu-4 ...
- PubMed Central (PMC)https://pmc.ncbi.nlm.nih.gov/articles/PMC419665/Crystal structure of the human T cell receptor CD3εγ heterodimer ...OKT3 interacts exclusively with a conformational epitope of the CD3ε subunit dominated by a linear stretch of sequence on the F–G loop. The OKT3/CD3ε interface ...
- https://www.genetex.com/Product/Detail/CD3-antibody-OKT3-PE/GTX79906-08Anti-CD3 antibody [OKT3] (PE) (GTX79906-08) | GeneTexThe OKT3 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex along with CD3 gamma and CD3 delta.
- PubMed Central (PMC)https://pmc.ncbi.nlm.nih.gov/articles/PMC1802437/Construction and characterization of a humanized anti-human CD3 ...12F6 is a murine anti-human CD3 monoclonal antibody, which competes with OKT3 for binding to human T cells and possesses more effective T-cell suppression ...
- https://www.sciencedirect.com/science/article/pii/S0008874900916174In Vitro Characterization of Five Humanized OKT3 Effector Function ...... sequence of the CH2 domain. J. Exp. Med., 173 (1991), p. 1025. View in Scopus ... Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Hum ...